ChemRxiv
These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
1/1
4 files

Iodine Catalyzed Synthesis of Substituted Furans and Pyrans: Reaction Scope and Mechanistic Insights

preprint
submitted on 03.07.2020 and posted on 06.07.2020 by Domenic Pace, Raphaël Robidas, Uyen P. N. Tran, Claude Legault, Thanh Vinh Nguyen
Substituted pyrans and furans are core structures found in a wide variety of natural products and biologically-active compounds. Herein, we report a practical and mild catalytic method for the synthesis of substituted pyrans and furans using molecular iodine, a simple and inexpensive catalyst. The method described herein is performed in solvent-free conditions in ambient temperature and atmosphere, thus offering a facile and green alternative to currently available reaction protocols. A combination of experimental studies and high‐level DFT calculations revealed interesting mechanistic insights of this seemingly simple reaction.

Funding

Novel organic architectures and functional materials from tropylium ions

Australian Research Council

Find out more...

Organic Linchpin Reagents to Construct Structural Diversity and Complexity

Australian Research Council

Find out more...

History

Email Address of Submitting Author

t.v.nguyen@unsw.edu.au

Institution

University of New South Wales, Sydney

Country

Australia

ORCID For Submitting Author

0000-0002-0757-9970

Declaration of Conflict of Interest

No conflict of interest to declare

Exports

Logo branding

Exports