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submitted on 03.07.2020 and posted on 06.07.2020by Domenic Pace, Raphaël Robidas, Uyen P. N. Tran, Claude Legault, Thanh Vinh Nguyen
Substituted pyrans and furans are core structures found in a wide variety of natural products and biologically-active
compounds. Herein, we report a practical and mild catalytic method for the synthesis of substituted pyrans and furans using molecular
iodine, a simple and inexpensive catalyst. The method described herein is performed in solvent-free conditions in ambient temperature
and atmosphere, thus offering a facile and green alternative to currently available reaction protocols. A combination of experimental
studies and high‐level DFT calculations revealed interesting mechanistic insights of this seemingly simple reaction.