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Iodine Catalyzed Synthesis of Substituted Furans and Pyrans: Reaction Scope and Mechanistic Insights

submitted on 03.07.2020, 05:55 and posted on 06.07.2020, 04:57 by Domenic Pace, Raphaël Robidas, Uyen P. N. Tran, Claude Legault, Thanh Vinh Nguyen
Substituted pyrans and furans are core structures found in a wide variety of natural products and biologically-active compounds. Herein, we report a practical and mild catalytic method for the synthesis of substituted pyrans and furans using molecular iodine, a simple and inexpensive catalyst. The method described herein is performed in solvent-free conditions in ambient temperature and atmosphere, thus offering a facile and green alternative to currently available reaction protocols. A combination of experimental studies and high‐level DFT calculations revealed interesting mechanistic insights of this seemingly simple reaction.


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University of New South Wales, Sydney



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Declaration of Conflict of Interest

No conflict of interest to declare


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