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Investigating the influence of aromatic moieties on the formulation of hydrophobic natural products and drugs in poly(2-oxazoline) based amphiphiles

preprint
submitted on 15.01.2018 and posted on 16.01.2018 by Robert Luxenhofer, Michael M Lübtow, Lukas Hahn, Thomas Lorson, Rainer Schobert
Many natural compounds with interesting biomedical properties share one physicochemical property, namely a low water solubility. Polymer micelles are, among others, a popular means to solubilize hydrophobic compounds. The specific molecular interactions between the polymers and the hydrophobic drugs are diverse and recently it has been discussed that macromolecular engineering can be used to optimize drug loaded micelles. Specifically, π-π stacking between small molecules and polymers has been discussed as an important interaction that can be employed to increase drug loading and formulation stability. Here, we test this hypothesis using four different polymer amphiphiles with varying aromatic content and various natural products that also contain different relative amounts of aromatic moieties. While in the case of paclitaxel, having the lowest relative content of aromatic moieties, the drug loading decreases with increasing relative aromatic amount in the polymer, the drug loading of curcumin, having a much higher relative aromatic content, is increased. Interestingly, the loading using schizandrin A, a dibenzo[a,c]cyclooctadiene lignan with intermediate relative aromatic content is not influenced significantly by the aromatic content of the polymers employed. The very high drug loading, long term stability, the ability to form stable highly loaded binary coformulations in different drug combinations, small sized formulations and amorphous structures in all cases, corroborate earlier reports that poly(2-oxazoline) based micelles exhibit an extraordinarily high drug loading and are promising candidates for further biomedical applications. The presented results underline that the interaction between the polymers and the incorporated small molecules are complex and must be investigated in every specific case.

History

Topic

  • Drug delivery systems
  • Organic Polymers

Email Address of Submitting Author

robert.luxenhofer@uni-wuerzburg.de

Email Address(es) for Other Author(s)

thomas.lorson@uni-wuerzburg.de michael.luebtow@uni-wuerzburg.de

Institution

Julius-Maximilians-University Würzburg

Country

Germany

ORCID For Submitting Author

0000-0001-5567-7404

Declaration of Conflict of Interest

no conflict of interest

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