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Intramolecular Cyclization of Vinyldiazoacetates as a Versatile Route to Substituted Pyrazoles.pdf (453.2 kB)
Intramolecular Cyclization of Vinyldiazoacetates as a Versatile Route to Substituted Pyrazoles
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submitted on 17.03.2020 and posted on 19.03.2020by Denis Drikermann, Valerie Kerndl, Helmar Görls, Ivan Vilotijevic
Vinyldiazo compounds undergo a thermal electrocyclization to form pyrazoles in yields of up to 95%. The reactions are operationally simple, use readily available starting materials, require no intervention of a catalyst, and enable the synthesis of mono-, di- and tri-substituted pyrazoles. With the ability to produce highly substituted pyrazole and the flexibility in installing various types of substituents, this method constitutes a new entry to this valuable heterocyclic scaffold of interest in all branches of chemical industry.