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Intramolecular Cyclization of Vinyldiazoacetates as a Versatile Route to Substituted Pyrazoles.pdf (453.2 kB)
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Intramolecular Cyclization of Vinyldiazoacetates as a Versatile Route to Substituted Pyrazoles

preprint
submitted on 17.03.2020 and posted on 19.03.2020 by Denis Drikermann, Valerie Kerndl, Helmar Görls, Ivan Vilotijevic
Vinyldiazo compounds undergo a thermal electrocyclization to form pyrazoles in yields of up to 95%. The reactions are operationally simple, use readily available starting materials, require no intervention of a catalyst, and enable the synthesis of mono-, di- and tri-substituted pyrazoles. With the ability to produce highly substituted pyrazole and the flexibility in installing various types of substituents, this method constitutes a new entry to this valuable heterocyclic scaffold of interest in all branches of chemical industry.

Funding

Carl Zeiss Foundation

Friedrich Schiller University Jena

Ernst Ludwig Ehrlich Foundation

State of Thuringia 2015 FGI0021

EU EFRE program

History

Email Address of Submitting Author

ivan.vilotijevic@uni-jena.de

Institution

Friedrich Schiller University Jena

Country

Germany

ORCID For Submitting Author

0000-0001-6199-0632

Declaration of Conflict of Interest

No conflict of interest.

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