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Intermolecular Phosphite-Mediated Radical Desulfurative Alkene Alkylation Using Thiols

preprint
submitted on 19.08.2019 and posted on 20.08.2019 by John Lopp, Valerie Schmidt

We report herein the development of an S-atom transfer process using triethyl phosphite as the S-atom acceptor that allows thiols to serve as precursors of C-centered radials. A range of functionalized and electronically unbiased alkenes including those containing common heteroatom-based functional groups. This process is driven by the exchange of relatively weak S-H and C-S bonds of aliphatic thiols for C-H, C-C, and S-P bonds of the products formed.

Funding

start-up funds from the University of California San Diego

History

Email Address of Submitting Author

vschmidt@ucsd.edu

Institution

University of California San Diego

Country

USA

ORCID For Submitting Author

0000-0001-9647-6756

Declaration of Conflict of Interest

no conflict of interest

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