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Interfacial Electro-Epoxidation in Electrospray Ionization Mass Spectrometry for Simultaneous Analysis of Negatively and Positively Charged Unsaturated Glycerophospholipids

preprint
submitted on 07.08.2020 and posted on 07.08.2020 by Shuli Tang, Licheng Fan, Heyong Cheng, Xin Yan
In this study, we developed an AC-induced interfacial electro-epoxidation reaction for localization of double-bonds in nega-tively and positively charged forms of lipids simultaneously. An AC voltage plays multiple roles in this method, including initiation of the electrochemical epoxidation of double-bonds in both charge states of lipids, and protonation and deprotona-tion of lipid for detection in both ion modes. The advantages of simultaneous detection of negatively changed and positively charged unsaturated lipids, voltage-controlled electrochemical derivatization, and the low sample consumption allow its wide applications in a broad range of lipid-related research.

History

Email Address of Submitting Author

xyan@tamu.edu

Institution

Texas A&M University

Country

U.S.A

ORCID For Submitting Author

0000-0002-8292-130X

Declaration of Conflict of Interest

No

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