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COVID-19 SARS-CoV-2_v04.pdf (1.41 MB)

Interaction of drugs candidates with various SARS-CoV-2 receptors: an in silico study to combat COVID-19

revised on 28.04.2020, 13:16 and posted on 29.04.2020, 07:14 by Romulo O. Barros, Fabio L. C. C. Junior, Wildrimak S. Pereira, Neiva M. N. Oliveira, Ricardo Ramos
The world is currently facing the COVID-19 pandemic caused by the SARS-CoV-2 virus. The pandemic is causing the death of people around the world and public and social health measures to slow or prevent the spread of COVID-19 are being implemented with the involvement of all members of society. Research institutions are accelerating the discovery of vaccines and therapies for the COVID-19. In this work, molecular docking was used to study (in silico) the interaction of twenty-four ligands, divided into four groups, with four important SARS-CoV-2 receptors. The results showed that Metaquine (group 01), antimalarial substance and the anti-HIV antiretroviral Saquinavir (group 03), presented interaction with all the studied receptors, indicating that they are potentials candidates for muti-target drugs for COVID-19.


Email Address of Submitting Author


Federal Institute of Piaui



ORCID For Submitting Author

Declaration of Conflict of Interest

The authors have declared that no competing interests exist

Version Notes

Minor changes were made.


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