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Inhibitory Effect of Eight Secondary Metabolites from Conventional Medicinal Plants on COVID_19 Virus Protease by Molecular Docking Analysis

preprint
submitted on 15.03.2020 and posted on 17.03.2020 by Narges Mohammadi, Neda Shaghaghi

Due to the reported high ability of virulence of COVID_19 in recent months, several studies have been conducted to discover and introduce COVID_19 antiviral drugs. The results of numerous studies have shown that protease inhibitors , which make up the major part of plant derivatives can therefore be very effective in controlling virus-induced infection. The aim of this research is the bioinformatical study of COVID_19 inhibition by Secendary Metabolite of medicinal herbs. This is a descriptive-analytic study. In the present study , the structure of Secendary Metabolite and COVID_19 protease was received from the databases such as PubChem and Protein Data Bank (PDB). After that, Molecular Docking was performed by MVD(molegro virtual docker) software.The results are identified to have inhibitory activities against novel COVID-19 protease. Of these compounds, Curcumin has a stronger bond and high affinity with protease. Finally, with due attention to the high effectiveness function of plant compounds, we can conclude that these compounds may be considered as effectire COVID_19 antiprotease drugs.

History

Email Address of Submitting Author

neda_2293@yahoo.com

Institution

cell and molecular biology department, faculty of basic science, university of maragheh

Country

Iran

ORCID For Submitting Author

0000-0003-3395-6466

Declaration of Conflict of Interest

no conflict

Exports