In silico Screening of Food Bioactive Compounds to Predict Potential Inhibitors of COVID-19 Main protease (Mpro) and RNA-dependent RNA polymerase (RdRp)
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As novel corona virus (COVID-19) infections has spread throughout the
world, world health organization (WHO) has announced COVID-19 as a pandemic
infection. Henceforth investigators are conducting extensive research to find possible
therapeutic agents against COVID-19. Main protease (Mpro) that plays an
essential role in processing the polyproteins that are translated from the 2019-nCOV RNA and RNA-dependent RNA polymerase (RdRp) that catalyzes the
replication of RNA from RNA template becomes as a potential targets for in silico
screening of effective therapeutic compounds to COVID-19. In this study we used
COVID-19 Docking Server to predict potential food bioactive compounds to inhibit
Mpro and RdRp. The results showed that Phycocyanobilin, Riboflavin, Cyanidin, Daidzein, Genistein
are potent inhibitor bioactive compounds to Mpro and RdRp in comparison to antiviral drugs. Though, further in
vitro and/or in vivo research is required to validate the docking results.