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In Vitro and In Vivo Sequestration of Phencyclidine by Me4Cucurbit[8]uril

preprint
submitted on 23.09.2020 and posted on 25.09.2020 by Steven Murkli, Jared Klemm, Adam T. Brockett, Michael Shuster, Volker Briken, Matthew R. Roesch, Lyle Isaacs
This work describes the in vitro binding of CB[8] and Me4CB[8] toward a panel of 10 drugs of abuse, and in vitro and in vivo assays to demonstrate the biocompatibility of Me4CB[8]. In vivo efficacy studies show that Me4CB[8] can control the hyper locomotion of animals treated with PCP.

Funding

National Institutes of Health (GM132345 and CA168365)

National Science Foundation (CHE-1404911)

Department of Education (GAANN, P200A150033)

History

Email Address of Submitting Author

lisaacs@umd.edu

Institution

University of Maryland, College Park

Country

United States

ORCID For Submitting Author

0000-0002-4079-332X

Declaration of Conflict of Interest

The University of Maryland has filed a patent on the material presented in this paper with S.M. and L.I. named as inventors.

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