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In Vitro and In Vivo Sequestration of Phencyclidine by Me4Cucurbit[8]uril

preprint
submitted on 23.09.2020, 14:10 and posted on 25.09.2020, 07:42 by Steven Murkli, Jared Klemm, Adam T. Brockett, Michael Shuster, Volker Briken, Matthew R. Roesch, Lyle Isaacs
This work describes the in vitro binding of CB[8] and Me4CB[8] toward a panel of 10 drugs of abuse, and in vitro and in vivo assays to demonstrate the biocompatibility of Me4CB[8]. In vivo efficacy studies show that Me4CB[8] can control the hyper locomotion of animals treated with PCP.

Funding

National Institutes of Health (GM132345 and CA168365)

National Science Foundation (CHE-1404911)

Department of Education (GAANN, P200A150033)

History

Email Address of Submitting Author

lisaacs@umd.edu

Institution

University of Maryland, College Park

Country

United States

ORCID For Submitting Author

0000-0002-4079-332X

Declaration of Conflict of Interest

The University of Maryland has filed a patent on the material presented in this paper with S.M. and L.I. named as inventors.

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