In Vitro and In Vivo Sequestration of Phencyclidine by Me4Cucurbit[8]uril

Steven Murkli; Jared Klemm; Adam T. Brockett; Michael Shuster; Volker Briken; Matthew R. Roesch; Lyle Isaacs

doi:10.26434/chemrxiv.12994004.v1

Organic Chemistry

Search within Organic Chemistry

In Vitro and In Vivo Sequestration of Phencyclidine by Me4Cucurbit[8]uril

25 September 2020, Version 1

Working Paper

Show author details

This content is a preprint and has not undergone peer review at the time of posting.

Abstract

This work describes the in vitro binding of CB[8] and Me4CB[8] toward a panel of 10 drugs of abuse, and in vitro and in vivo assays to demonstrate the biocompatibility of Me4CB[8]. In vivo efficacy studies show that Me4CB[8] can control the hyper locomotion of animals treated with PCP.

Keywords

cucurbituril

sequestration agent

phencyclidine hydrochloride

molecular recognition

hyperlocomotion assay

Supplementary materials

Title

Description

Actions

Title

Me4CB8 Reversal Paper SI 20200922 pdfa

Description

Actions

Comments

Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here .

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Now Published

In Vitro and In Vivo Sequestration of Phencyclidine by Me 4 Cucurbit[8]uril**

Steven Murkli, Jared Klemm, Adam T. Brockett, Michael Shuster, Volker Briken, Matthew R. Roesch, Lyle Isaacs journal article

Chemistry – A European Journal , Volume 27, Issue 9

Online publication date: Jan 19, 2021

Version History

Sep 25, 2020 Version 1

Metrics

1,848

796

Views

Downloads

License

The content is available under CC BY NC ND 4.0

DOI

10.26434/chemrxiv.12994004.v1

Funding

National Institutes of Health (GM132345 and CA168365)

National Science Foundation (CHE-1404911)

Department of Education (GAANN, P200A150033)

Author’s competing interest statement

The University of Maryland has filed a patent on the material presented in this paper with S.M. and L.I. named as inventors.

In Vitro and In Vivo Sequestration of Phencyclidine by Me4Cucurbit[8]uril

Authors

Abstract

Keywords

Supplementary materials

Comments

Now Published

Version History

Metrics

License

DOI

Funding

Author’s competing interest statement

Share