In Silico Screening of Some Antiviral Phytochemicals as Drug Leads Against Covid-19
Preprints are manuscripts made publicly available before they have been submitted for formal peer review and publication. They might contain new research findings or data. Preprints can be a draft or final version of an author's research but must not have been accepted for publication at the time of submission.
Background: COVID-19 caused by SARS-CoV-2 in December 2019 has become a pandemic
hazard to the community health. It is a respiratory difficulty causing fever, dry cough, fatigue,
shortness of breath, muscle aches and some instances lead to pneumonia. Coronaviruses have
large viral RNA Genomes and are single-stranded positive-sense RNA viruses. The nsp10/nsp16
protein is an important target because it is essential for the virus to replicate, the papain-like
protease (Nsp3), the main protease (Nsp5), the primary RNA-dependent RNA polymerase
(Nsp12) are also attractive drug targets for this disease. The uses of phytochemicals as
therapeutic agents have been increasing in recent years. Some antiviral phytochemicals were
taken based on literature survey for this study.
Methods: ADME parameters and drug like nature of phytochemicals were screened using
SwissADME web tool. Three dimensional structures of targets are downloaded from Protein
Data Bank and docked with phytochemicals & control by using software FlexX.
Results: Morin shows significant results in ADME screening and Drug likeness prediction
studies, it shows stable bonding pattern with all four targets in compare to other phytochemicals
and control, shows least score in docking and forms maximum number of hydrogen bonds with
the active residues of the receptors.
Conclusion: Based on present observation of docking results, ADME parameters and drug like
nature, we suggest that morin may be a potent new drug candidate against Covid-19.
Keywords: COVID-19, coronavirus, drug target, phytochemicals, Drug likeness, ADME,