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In Search for Effective and Safe Drugs Against SARS-CoV-2: Part II] the Role of Selected Salts and Organometallics of Copper, Zinc, Selenium, and Iodine Food Supplements

preprint
submitted on 02.05.2020 and posted on 05.05.2020 by M. Sabry Abdel-Mottaleb, Yousra Abdel-Mottaleb
Three organometallics and three inorganic food supplements were selected, and their binding to specific peptide sequences of the coronavirus S-protein: ACE2 interface-drug binding adduct were computed. The chosen molecules located themselves to achieve geometries of minimum energy resulting in limiting viral recognition of the host cells or disturbing the host-virus interactions. Electrophilicity and nucleophilicity indices, based on the HOMO – LUMO frontier orbitals, were successfully used to explain the simulation results. Zinc and copper-supplements act as electron donors (nucleophiles) towards the ACE2 (electrophile), whereas the S protein remains inert. Molecular iodine acts as a strong electron sink in all of its unstable adducts with the ACE2, or the S protein, and in its adduct with both. Iodine is a stand-in as an electron shield to the ACE2. Currently, exploiting iodine has not been attempted, and it has been forgotten; while it has been used successfully in the treatment of the Spanish flu that started early 1918 and killed 30 million people. The results obtained strongly suggest the beneficial use of iodine. Selenodiglutathione exhibits strong electrophilic property and turns the S protein into an electron sink virus in the presence of ACE2, which behaves like an electron donor. Contrary to zinc gluconate and iodine, the presence of selenomethionine, copper sulfate, selenodiglutathione, or sodium selenite strengthens the ACE2 – S protein interaction. The results reported indicate the association of common food supplements to offer protection and/or treatment against coronavirus S-protein COVID-19. These findings indicate also that these simple methods could help with the fight against COVID-19.

Funding

No Funding

History

Email Address of Submitting Author

m.s.abdelmottaleb@sci.asu.edu.eg

Institution

Ain Shams University, Faculty of Science, Department of Chemistry

Country

Egypt

ORCID For Submitting Author

0000-0002-4437-7040

Declaration of Conflict of Interest

no conflict of interest

Version Notes

Prelimenary Results

Exports