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In-Silico Interaction of Hydroxychloroquine Drug with Various Proteins of Coronavirus (SARS-CoV-2): A Computational Approaches to Combat COVID-19

preprint
submitted on 12.06.2020 and posted on 15.06.2020 by Rishee Kalaria, Hiren K. Patel

In silico docking study showed that hydroxychloroquine drug interactions with SARS-CoV2 show a higher binding affinity with spike glycoprotein and PLPRO protein compared to protein envelopes that could be ladder for potential targeting and synthesizing of another aniviral drug. In silico methods used in this study, the efficacy of a wide variety of repositioned and/or novel drug candidates could also be tested prior to clinical evaluation.

History

Email Address of Submitting Author

risheekal@nau.in

Institution

Navsari Agricultural University

Country

India

ORCID For Submitting Author

0000-0002-4481-3834

Declaration of Conflict of Interest

Conflict of Interest: The authors declare no potential conflicts of interest.

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