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ChemRxiv_Flow_Nanoprecipitation_Gioiello.pdf (351.4 kB)

In-Flow Flash Nanoprecipitation of Size-Controlled D-Leucine Nanoparticles for Spray-Drying Formulations

submitted on 03.05.2019, 08:05 and posted on 06.05.2019, 16:53 by Bruno Cerra, Mosca Gabriele, Maurizio Ricci, Aurelie Schoubben, Antimo Gioiello

In this work we report the development of a cheap and scalable flow-based flash nanoprecipitation approach to prepare D-leucine nanoparticles particularly useful as glidants in dry powder for inhalation. Starting from preliminary batch screens, the process was successfully optimized and scaled-up under mesofluidic conditions. The nebulization with both mini and nano spray-dryer, the SEM analysis of nanoparticles and the aerodynamic evaluation of a formulation obtained by physical mixing of atomized D-leucine powders with budenoside showed an excellent decrease in particle size without altering the morphology, and a marked improvement in the aerodynamic properties of the drug. This simple and economic method by physical mixing of leucine with micronized active pharmaceutical ingredients can represent a valid alternative to co-spray-drying.


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University of Perugia



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Declaration of Conflict of Interest

No conflict of interest