ChemRxiv
These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
1/1
2 files

Implanted chemical sensors for functional radiography

preprint
submitted on 21.09.2017 and posted on 22.09.2017 by Md Arifuzzaman, Paul W. Millhouse, Yash Raval, Thomas B. Pace, Caleb J. Behrend, John D. DesJardins, Tzuen-Rong J. Tzeng, Jeffrey N. Anker
A biomedical sensor is designed to noninvasively measure local pH changes on the surface of implanted devices for detecting and monitoring implant-associated infection using plain radiography. The sensor comprises a radiopaque pin embedded within a polyacrylic acid-based hydrogel. pH-modulated hydrogel expansion and contraction is determined by radiographically measuring the pin position. The sensor was calibrated in a series of standard pH buffers, and tested in a bacterial growth culture. The sensor calibration was insensitive to changes in temperature and ionic strength within the normal physiological range. The response time depended on sensor thickness, and was approximately 30 min for 1 mm thick films. Radiographic measurements were also performed through tissue and bone with the sensor attached to an orthopedic plate fixated to a human cadaver tibia. Plain radiographs were selected for readout since X-rays are routinely used in inpatient and outpatient settings for structural or anatomical information. The chemically-responsive hydrogel sensors can provide additional functional information in a clinical setting by indicating local chemical concentrations near the implant surface using routinely obtained radiographs.

Funding

This work was fully supported by the US government funding under R-01 (5R01AR070305) and SCBioCRAFT, COBRE (5P20GM10344407) grants awarded by the National Institutes of Health. This work is also a part of pending Patent Cooperation Treaty (PCT) application (serial: 62/204, 111, with a filing date of August 12, 2015).

History

Topic

  • Analytical Chemistry
  • Imaging
  • Biochemical Analysis

Email Address of Submitting Author

marifuz@g.clemson.edu

Email Address(es) for Other Author(s)

janker@clemson.edu

Institution

Clemson University

Country

USA

ORCID For Submitting Author

0000-0002-3041-7320

Declaration of Conflict of Interest

The authors declare no conflict of interest.

Exports