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Impedimetric Characterization of Bioelectronic Nano-Antennae

revised on 22.10.2020, 05:47 and posted on 22.10.2020, 06:55 by Andie Robinson, Akhil Jain, Ruman Rahman, Sidahmed Abayzeed, Richard Hague, Frankie Rawson

The merging of electronics with biology at the nanoscale holds considerable promise for sensing and modulating cellular behavior. Advancing our understanding of nano-bioelectronics will facilitate development and enable applications in biosensing, tissue engineering and bioelectronic medicine. However, studies investigating the electrical effects when merging wireless conductive nanoelectrodes with biology are lacking. Consequently, a new tool is required to develop a greater understanding of the bioelectrical effects of merging conductive nanoparticles with biology. Herein, this challenge is addressed by developing an impedimetric method to evaluate bipolar electrochemical systems (BESs) that could act as nano-antennas. A theoretical framework is provided, using impedance to determine if conductive nanoparticles can be polarized and used to drive current. It is then demonstrated that 125 nm Au nanoparticle bipolar electrodes (BPEs) could be sensed in the presence of biology when incorporated intracellularly at 500 mg/ml, using water and PBS as electrolytes. These results highlight how nanoscale BPEs act within biological systems and characterize their behavior in electric fields. This research will impact on the rational design of using BPE systems in biology for both sensing and actuating applications.


Wireless communication with cells towards bioelectronic treatments of the future

Engineering and Physical Sciences Research Council

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EPSRC and MRC Centre for Doctoral Training in Regenerative Medicine

Engineering and Physical Sciences Research Council

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Email Address of Submitting Author


Univeristy of Nottingham


United Kingdom

ORCID For Submitting Author


Declaration of Conflict of Interest

The authors declare that there are no conflicts of interest.

Version Notes

version 1 of document