ChemRxiv
These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
Impedimetric Charaterization of Bioelectronic Nano-antennae Small v3.pdf (1.25 MB)

Impedimetric Characterization of Bioelectronic Nano-Antennae

preprint
submitted on 02.07.2020 and posted on 03.07.2020 by Andie Robinson, Akhil Jain, Ruman Rahman, Sidahmed Abayzeed, Richard Hague, Frankie Rawson

The merging of electronics with biology at the nanoscale holds considerable promise for sensing and modulating cellular behavior. Advancing our understanding of nano-bioelectronics will facilitate development and enable applications in biosensing, tissue engineering and bioelectronic medicine. However, studies investigating the electrical effects when merging wireless conductive nanoelectrodes with biology are lacking. Consequently, a new tool is required to develop a greater understanding of the bioelectrical effects of merging conductive nanoparticles with biology. Herein, this challenge is addressed by developing an impedimetric method to evaluate bipolar electrochemical systems (BESs) that could act as nano-antennas. A theoretical framework is provided, using impedance to determine if conductive nanoparticles can be polarized and used to drive current. It is then demonstrated that 125 nm Au nanoparticle bipolar electrodes (BPEs) could be sensed with biology when incorporated extracellularly. These results highlight how nanoscale BPEs act in biology and characterize their behavior in electric fields. This research will impact on the rational design of using BPE systems in biology for both sensing and actuating applications.

Funding

Wireless communication with cells towards bioelectronic treatments of the future

Engineering and Physical Sciences Research Council

Find out more...

EPSRC and MRC Centre for Doctoral Training in Regenerative Medicine

Engineering and Physical Sciences Research Council

Find out more...

History

Email Address of Submitting Author

frankie.rawson@nottingham.ac.uk

Institution

Univeristy of Nottingham

Country

United Kingdom

ORCID For Submitting Author

0000-0002-4872-8928

Declaration of Conflict of Interest

The authors declare that there are no conflicts of interest.

Version Notes

version 1 of document

Exports