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Impact of Conformations and Size on the Antileishmanial Activity of New Quinazoline Derivatives

preprint
submitted on 31.07.2020, 16:35 and posted on 03.08.2020, 08:22 by Cesar Mendoza-Martinez, Alejandro Rodriguez-Lezama, Norma Galindo-Sevilla, Fernando Cortés-Guzmán, Jessica Hernandez-Pineda, Abril Nieto-Lara, Francisco Hernandez-Luis
There is an urgency of finding molecules available to treat Leishmaniasis, which is one of the significant issues of health in undeveloped countries. For that reason is needed to explore molecular diversity to find novel scaffolds. Fluorinated and adamantane derivatives exhibit a formidable starting point. They are proved to improve the antileishmanial activity when attached to molecules already active as we have shown in this paper. Particularly fluorinated methoxy and ethoxy derivatives can increase its volume depending on the number of fluorine, a unique behaviour that can be exploited for molecular drug design purposes.

Funding

UNAM-DGAPA-PAPIIT IN223120

CONACYT-SEP-CB220664

History

Email Address of Submitting Author

cesar.mendoza@ed.ac.uk

Institution

UNAM, TECSIQUIM S.A. de C.V.

Country

Mexico

ORCID For Submitting Author

0000-0003-3439-9809

Declaration of Conflict of Interest

There is no conflict of interests

Version Notes

Revision01. First revision only

Exports