Identification of Diphenoxylate as an Antiviral Agent Against Severe Acute Respiratory Syndrome Coronavirus 2

19 June 2020, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

This is the first report to show that diphenoxylate is highly active against SARS-CoV-2 with EC50 of 1.4 μM, CC50 over 100 μM and selectivity index over 71.4 after screening of 14 diphenyl derivatives. Our results with highly purified solid diphenoxylate confirmatively demonstrate that the viral S protein is reduced in the virus-infected cells in a dose-dependent manner. It could provide insights for antiviral treatment of COVID-19 with diphenoxylate or its chemical derivatives

Keywords

SARS-CoV-2
antiviral
diphenoxylate
diphenylpropyl piperidine

Supplementary materials

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