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Identification of Diphenoxylate as an Antiviral Agent Against Severe Acute Respiratory Syndrome Coronavirus 2

preprint
submitted on 17.06.2020 and posted on 19.06.2020 by Jin Soo Shin, Eunhye Jung, Yejin Jang, Soo Bong Han, Meehyein Kim
This is the first report to show that diphenoxylate is highly active against SARS-CoV-2 with EC50 of 1.4 μM, CC50 over 100 μM and selectivity index over 71.4 after screening of 14 diphenyl derivatives. Our results with highly purified solid diphenoxylate confirmatively demonstrate that the viral S protein is reduced in the virus-infected cells in a dose-dependent manner. It could provide insights for antiviral treatment of COVID-19 with diphenoxylate or its chemical derivatives

Funding

National Research Foundation of Korea (NRF-2020M3A9I2081687)

History

Email Address of Submitting Author

mkim@kirct.re.kr

Institution

Korea Research Institute of Chemical Technology

Country

Republic of Korea

ORCID For Submitting Author

0000-0002-2851-5298

Declaration of Conflict of Interest

No conflict of interest

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