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Hypoxia-activated Probe for NIR Fluorescence and Photoacoustic Dual-mode Tumor Imaging
preprintsubmitted on 30.11.2020, 10:08 and posted on 02.12.2020, 07:22 by Meng Li, Huan Li, Qian Wu, Niu Niu, Jiachang Huang, Lingmin Zhang, Ying Li, Dong Wang, Ben Zhong Tang
We rationally designed and synthesized a hypoxia-responsive probe TBTO featuring four diethylamino N-oxide groups that could undergo bioreduction in a hypoxic microenvironment, producing TBT with a typical D-A-D structure. It was demonstrated that TBT possesses NIR fluorescence emission and PA signal generation, benefiting from its both AIE property and a strong TICT effect. In vitro and in vivo assessments revealed the responsiveness of TBTO in a reductive environment and its NIR fluorescence and PA dual-mode imaging ability.