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revised on 21.08.2020 and posted on 21.08.2020by Carmanah
D. Hunter, Elizabeth Porter, Christopher Cairo
This work investigated the substrate specificity of hNEU enzymes for a
glycoprotein substrate (bovine submaxillary mucin) containing 9-O-acetylated
and Neu5Gc residues. Using this model substrate, we observe a general trend for
hNEU tolerance of Neu5Ac>Neu5Gc>>>Neu5,9Ac2, consistent
with our previous results with glycolipid substrates. These results expand our
understanding of hNEU enzyme specificity and suggest that naturally occurring
modifications of sialic acids can play a role in regulating hNEU activity.