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Homology Models of Wuhan Coronavirus 3CLpro Protease
preprintsubmitted on 19.01.2020, 16:20 and posted on 24.01.2020, 21:25 by Martin Stoermer
A regional outbreak of pneumonia in Wuhan, Hubei Province of China in late 2019 was associated with a novel coronavirus. Rapid release of genomic data for the isolated virus enabled the construction of first-generation homology models of the new CoV 3CLpro cysteine protease. Whilst the overall viral genome was most closely associated with bat coronaviruses, the main protease is most closely related (96% identity) to SARS CoV protease.