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Highly Enantioselective Hiyama Cross-Coupling via Rh-Catalyzed Allylic Arylation of Racemic Allyl Chlorides

preprint
submitted on 13.08.2018 and posted on 13.08.2018 by Jesus Gonzalez, Philipp Schäfer, Stephen P. Fletcher

Highly enantioselective Hiyama cross-coupling reactions have been achieved through rhodium(I)-catalyzed dynamic kinetic asymmetric transformations between aryl siloxanes and racemic allyl halides. This process affords valuable enantiomerically enriched allyl arenes and is compatible with heterocyclic allyl chloride electrophiles.

Funding

Engineering and Physical Sciences Research Council (EP/N022246/1), Marie Skłodowska-Curie fellowship (GA 700108)

History

Email Address of Submitting Author

stephen.fletcher@chem.ox.ac.uk

Institution

University of Oxford

Country

United Kingdom

ORCID For Submitting Author

0000-0001-7629-0997

Declaration of Conflict of Interest

No conflict of interest

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