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Harnessing Chemical Energy for the Activation and Joining of Prebiotic Building Blocks

submitted on 26.11.2019, 16:00 and posted on 02.12.2019, 11:30 by Ziwei Liu, Long-Fei Wu, Jianfeng Xu, Claudia Bonfio, Russell David, John Sutherland
Simultaneous activation of carboxylates and phosphates provides multiple pathways for the generation of reactive intermediates, including mixed carboxylic acid-phosphoric acid anhydrides, for the synthesis of peptidyl-RNAs, peptides, RNA oligomers and primordial phospholipids. These results indicate that unified prebiotic activation chemistry could have enabled the joining of building blocks in aqueous solution from a common pool and enabled the progression of a system towards higher complexity foreshadowing the modern encapsulated peptide-nucleic acid system


Email Address of Submitting Author


MRC Laboratory of Molecular Biology


United Kingdom

ORCID For Submitting Author


Declaration of Conflict of Interest

The authors declare no competing financial interests.