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Graphene-Oxide Based Fluorescent DNA Aptasensor for Liver Cancer Diagnosis and Therapy

submitted on 10.03.2021, 02:23 and posted on 10.03.2021, 13:20 by Ke Ma, Wei Xie, Wei Liu, Lei Wang, Dong Wang, Ben Zhong Tang
Graphene-oxide based fluorescent DNA aptasensors for the in vivo application remain a challenging task. We demonstrate for the first time such a nanomaterial for in vivo diagnosis and therapy of liver tumor with good biocompatibility and high selectivity. This DNA nanomaterial comprising of DNA tetrahedron and aptamers, aggregation-induced emission luminogen (AIEgens) and antitumor drug doxorubicin, is fabricated and attached on GO surface. Additionally, this GO-based fluorescent DNA nanodevice is also constructed by using microfluidic chip for liver tumor cell screening.


Email Address of Submitting Author


Materials Science and Engineering, Shenzhen University



ORCID For Submitting Author


Declaration of Conflict of Interest

No conflict of interest.