These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
Golden Opportunity - ChemRxiv Manuscript-unformatted.pdf (1.31 MB)

Golden Opportunity: A Clickable Azide-Functionalized [Au25(SR)18]-Nanocluster Platform for Interfacial Surface Modifications

submitted on 14.05.2019 and posted on 16.05.2019 by Praveen Gunawardene, John F. Corrigan, Mark Workentin
Ultrasmall atomically precise monolayer-protected gold thiolate nanoclusters are an intensely researched nanomaterial framework, but there is a lack of a system that can be directly synthesized and undergo interfacial surface chemistry. We report an [Au25(SCH2CH2-p-C6H4-N3)18]- nanocluster platform with azide moieties appended onto each surface ligand. The structure of this surface reactive cluster has been confirmed by single-crystal X-ray crystallography, mass spectrometry and UV-Vis, IR and NMR spectroscopies. We show that all surface azide moieties are amenable to cluster-surface strain-promoted alkyne-azide cycloaddition (CS-SPAAC) chemistry with a strained cyclooctyne, opening this as a new platform to allow functional, post-assembly surface modifications to this very prominent nanocluster.


Email Address of Submitting Author


The University of Western Ontario



ORCID For Submitting Author


Declaration of Conflict of Interest


Version Notes

submitted version