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Gliptin_repurposing_for_COVID-19.docx (5.58 MB)

Gliptin Repurposing for COVID-19

preprint
submitted on 10.04.2020 and posted on 15.04.2020 by Matthew Groves, Alexander Domling, Angel Jonathan Ruiz Moreno, Atilio Reyes Romero, Constantinos Neochoritis, Marco Velasco-Velázquez
De novo drug discovery of any therapeutic modality (e.g. antibodies, vaccines or small molecules) historically takes years from idea/preclinic to the market and it is therefore not a short-term solution for the current SARS-CoV-2 pandemic. Therefore, drug repurposing – the discovery novel indication areas for already approved drugs - is perhaps the only approach able to yield a short term relieve. Here we describe computational screening results suggesting that certain members of the drug class of gliptins are inhibitors of the two SARS-CoV-2 proteases 3CLpro and PLpro. The oral bioavailable antidiabetic drug class of gliptins are safe and have been introduced clinically since 2006 and used by millions of patients since then. Based on our repurposing hypothesis the nitrile containing gliptins deserve further investigation as potential anti-COVID19 drugs.

History

Email Address of Submitting Author

a.s.s.domling@rug.nl

Institution

University of Groningen

Country

The Netherlands

ORCID For Submitting Author

0000-0002-9923-8873

Declaration of Conflict of Interest

NA

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