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ChoRetraction2FHA_ChemRxiv.pdf (70.23 kB)

Site-selective enzymatic C‒H amidation for synthesis of diverse lactams

preprint
revised on 03.01.2020 and posted on 03.01.2020 by Inha Cho, Zhijun Jia, Frances H. Arnold

Please note that this work has been retracted by the authors.


After publication of the Report “Site-selective enzymatic C‒H amidation for synthesis of diverse lactams” in Science (1, also linked in metadata), efforts to reproduce the work showed that the enzymes do not catalyze the reactions with the activities and selectivities claimed. Careful examination of the first author’s lab notebook then revealed missing contemporaneous entries and raw data for key experiments. The authors therefore have retracted the article from Science and are now retracting the preprint from ChemRxiv. The original paper can be accessed by selecting “Version 1” of the preprint below, or by accessing https://doi.org/10.26434/chemrxiv.7711418.v1.


Inha Cho, Zhi-Jun Jia, Frances H. Arnold*


Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.


*Corresponding author. Email: frances@cheme.caltech.edu


References

1. I. Cho, Z.-J. Jia, F. H. Arnold, Science 364, 575 (2019). DOI: 10.1126/science.aaw9068



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Directed evolution of cytochrome P450 enzymes fine-tunes site selectivity of new-to-nature C‒H amidation for modular, sustainable and scalable preparation of enantio-enriched β-, γ- and δ-lactams.

History

Email Address of Submitting Author

zhijia@caltech.edu

Institution

California Institute of Technology

Country

USA

ORCID For Submitting Author

0000-0002-5143-4875

Declaration of Conflict of Interest

Caltech has filed a provisional patent application (CIT-8187-P)

Exports