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Genetically Encoded Fragment-Based Discovery (GE-FBD) from Phage-Displayed Macrocyclic Libraries with Genetically-Encoded Unnatural Pharmacophores

preprint
submitted on 12.07.2020, 01:35 and posted on 13.07.2020, 13:14 by ARUNIKA EKANAYAKE, Lena Sobze, Jihea Youk, Nicholas J. Bennett, Raja Mukherjee, Atul Bhardwaj, Frank Wuest, Ratmir Derda

Genetically encoded fragment-based discovery (GE-FBD) from phage-displayed macrocyclic libraries with genetically-encoded unnatural pharmacophores

Late stage functionalization of genetically encoded 1,3-diketone macrocyclic phage libraries by pharmacophores containing hydrazine handles.

Funding

RGPIN-2016-402511

History

Email Address of Submitting Author

ratmir@ualberta.ca

Institution

University of Alberta

Country

Canada

ORCID For Submitting Author

0000-0003-1365-6570

Declaration of Conflict of Interest

R.D. is the C.E.O. and a shareholder of 48Hour Discovery Inc., the company that licensed the patent application describing silent encoding and chemical modification technologies.

Version Notes

This is the first version.

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