Genetically Encoded Fragment-Based Discovery (GE-FBD) from Phage-Displayed Macrocyclic Libraries with Genetically-Encoded Unnatural Pharmacophores

13 July 2020, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Genetically encoded fragment-based discovery (GE-FBD) from phage-displayed macrocyclic libraries with genetically-encoded unnatural pharmacophores

Late stage functionalization of genetically encoded 1,3-diketone macrocyclic phage libraries by pharmacophores containing hydrazine handles.

Keywords

Macrocycles
Phage display
1,3-diketone
Hydrazine

Supplementary materials

Title
Description
Actions
Title
Data
Description
Actions
Title
Derda SI
Description
Actions

Comments

Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.