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Further SAR on the (Phenylsulfonyl)piperazine Scaffold as Inhibitors of the Aedes Aegypti Kir1 (AeKir) Channel and Larvicides

submitted on 16.07.2020, 16:53 and posted on 20.07.2020, 11:30 by Christopher D. Aretz, Sujay V. Kharade, Keagan S. Chronister, Erick J. Martinez Rodriguez, Peter M. Piermarini, Jerod S. Denton, Corey Hopkins, Renata Rusconi Trigueros
We have discovered new chemical compounds that are characterized as Kir channel inhibitors of the Aedes aegypti mosquito. This is important as the Ae. aegypti mosquito is the primary vector for Zika virus (ZIKV), Dengue virus (DENV) and chikungunya virus (CHIKV). Traditional mosquitocides are plagued with significant resistance and developing new compounds with novel mechanisms of action are vitally important. Lastly, we show that our compounds are potent larvicides against pyrethroid-susceptible and pyrethroid-resistant strains.


R21 AI128418


Email Address of Submitting Author


University of Nebraska Medical Center


United States

ORCID For Submitting Author


Declaration of Conflict of Interest

The authors declare no Conflict of Interest.