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Frequency Selective Phase-Optimized Recoupling for Protons in Ultra-Fast Solid-State Magic-Angle Spinning NMR

submitted on 22.05.2020 and posted on 22.05.2020 by Zhengfeng Zhang, Andres Oss, Mai-Liis Org, Ago Samoson, Huan Tan, Jun Yang

We propose a new category of homonuclear frequency-selective recoupling methods for protons under ultra-fast MAS ranging from 40 kHz to 150 kHz. The methods, named as Selective Phase-optimized Recoupling (SPR) are simple in the form with defined phase schemes and RF amplitudes. SPR are robust to RF variations and efficient in frequency-selective recoupling. We demonstrated that SPR can provide a sensitivity gain of ~ 3 over the widely-used RFDR for selective 1HN-1HN correlations under 150 kHz MAS using a protonated tripeptide N-formyl-Met-Leu-Phe (fMLF). Moreover, SPR requires small ratios (~ 0.5) of RF power with respect to MAS frequency, making it perfect to probe long-range 1H-1H distance under ultra-fast MAS up to 150 kHz.


National Natural Science Foundation of China

National Key R&D Program of China

Estonian Research Agency


Email Address of Submitting Author


Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences



ORCID For Submitting Author


Declaration of Conflict of Interest

The authors declare no competing financial interest.