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Frequency Selective Phase-Optimized Recoupling for Protons in Ultra-Fast Solid-State Magic-Angle Spinning NMR

preprint
submitted on 22.05.2020 and posted on 22.05.2020 by Zhengfeng Zhang, Andres Oss, Mai-Liis Org, Ago Samoson, Huan Tan, Jun Yang

We propose a new category of homonuclear frequency-selective recoupling methods for protons under ultra-fast MAS ranging from 40 kHz to 150 kHz. The methods, named as Selective Phase-optimized Recoupling (SPR) are simple in the form with defined phase schemes and RF amplitudes. SPR are robust to RF variations and efficient in frequency-selective recoupling. We demonstrated that SPR can provide a sensitivity gain of ~ 3 over the widely-used RFDR for selective 1HN-1HN correlations under 150 kHz MAS using a protonated tripeptide N-formyl-Met-Leu-Phe (fMLF). Moreover, SPR requires small ratios (~ 0.5) of RF power with respect to MAS frequency, making it perfect to probe long-range 1H-1H distance under ultra-fast MAS up to 150 kHz.

Funding

National Natural Science Foundation of China

National Key R&D Program of China

Estonian Research Agency

History

Email Address of Submitting Author

zhangzf@wipm.ac.cn

Institution

Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences

Country

China

ORCID For Submitting Author

0000-0003-2025-8327

Declaration of Conflict of Interest

The authors declare no competing financial interest.

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