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Formation of Enamines via Catalytic Dehydrogenation by Pincer-Iridium Complexes

preprint
submitted on 19.10.2019 and posted on 23.10.2019 by Xiawei Zhang, Santanu Malakar, Karsten Krogh-Jespersen, Faraj Hasanayn, Alan Goldman
Efficient pincer-ligated iridium catalysts are reported for the dehydrogenation of simple tertiary amines to give enamines, and for the dehydrogenation of β-functionalized amines to give the corresponding 1,2-difunctionalized olefins. Experimentally determined kinetic isotope effects in conjunction with DFT-based analysis support a dehydrogenation mechanism involving initial pre-equilibrium oxidative addition of the amine α C-H bond followed by rate-determining elimination of the β-C-H bond.

Funding

National Science Foundation CHE-1465203

History

Email Address of Submitting Author

alan.goldman@rutgers.edu

Institution

Rutgers University

Country

United States

ORCID For Submitting Author

0000-0002-2774-710X

Declaration of Conflict of Interest

No conflict of interest.

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