ChemRxiv
These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
Formal Synthesis of Actinoranone.pdf (3.21 MB)
0/0

Formal Synthesis of Actinoranone Using a Racemization-Free One-Pot Semipinacol Rearrangement/Wittig Reaction

preprint
submitted on 16.09.2018 and posted on 18.09.2018 by Martina Menger, Mathias Christmann
Here, we report a formal synthesis of the marine cytotoxic meroterpenoid actinoranone. Key steps include a racemization-free semipinacol rearrangement/Wittig reaction sequence and a chiral pool approach for the syntheses of the tetralone and the decalin fragments, respectively. The presented route provides access to the natural product in 14 steps in the longest linear sequence.

History

Email Address of Submitting Author

mathias.christmann@fu-berlin.de

Institution

Freie Universität Berlin

Country

Germany

ORCID For Submitting Author

0000-0001-9313-2392

Declaration of Conflict of Interest

No conflict of interest

Version Notes

Final version before submission

Exports