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Fatty Acid Fueled Transmembrane Chloride Transport

preprint
revised on 31.05.2019 and posted on 03.06.2019 by Ethan N.W. Howe, Philip Gale
We report an example of the use of fatty acids to drive chloride transport by creating a pH gradient across a vesicular lipid bilayer membrane. Addition of an unselective squaramide-based chloride transporter (which transports both H+and Cl-) facilitates the transport of HCl from the vesicle (driven by the pH gradient) so creating a chloride gradient. Addition of further aliquots of fatty acid ‘fuel’ can initiate further transport of chloride out of the vesicle by re-establishing the pH gradient. This is an example of a prototypical chloride pumping system.

Funding

Australian Research Council (DP180100612)

History

Email Address of Submitting Author

philip.gale@sydney.edu.au

Institution

The University of Sydney, School of Chemistry (F11)

Country

Australia

ORCID For Submitting Author

0000-0001-9751-4910

Declaration of Conflict of Interest

No conflict of interest

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in Journal of the American Chemical Society

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