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Fatty Acid Fueled Transmembrane Chloride Transport

preprint
revised on 31.05.2019, 21:42 and posted on 03.06.2019, 15:13 by Ethan N.W. Howe, Philip Gale
We report an example of the use of fatty acids to drive chloride transport by creating a pH gradient across a vesicular lipid bilayer membrane. Addition of an unselective squaramide-based chloride transporter (which transports both H+and Cl-) facilitates the transport of HCl from the vesicle (driven by the pH gradient) so creating a chloride gradient. Addition of further aliquots of fatty acid ‘fuel’ can initiate further transport of chloride out of the vesicle by re-establishing the pH gradient. This is an example of a prototypical chloride pumping system.

Funding

Australian Research Council (DP180100612)

History

Email Address of Submitting Author

philip.gale@sydney.edu.au

Institution

The University of Sydney, School of Chemistry (F11)

Country

Australia

ORCID For Submitting Author

0000-0001-9751-4910

Declaration of Conflict of Interest

No conflict of interest

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in Journal of the American Chemical Society

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