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Fast Carbon Isotope Exchange of Carboxylic Acids Enabled by Organic Photoredox Catalysis

preprint
submitted on 19.10.2020, 17:39 and posted on 20.10.2020, 10:06 by Duanyang Kong, Maxime Munch, Qiqige Qiqige, Christopher Cooze, Benjamin Rotstein, Rylan Lundgren
Carbazole/cyanobenzene photocatalysts promote the direct isotopic carboxylate exchange of C(sp3 )-acids with labelled CO2. Substrates that are not compatible with transition metal catalyzed degradation-reconstruction approaches or prone to thermally induced reversible decarboxylation undergo isotopic incorporation at room temperature in short reaction times. The radiolabelling of drug molecules and precursors with [11C]CO2 is demonstrated.

Funding

NSERC RGPIN-2019-06050

NSERC RGPAS-2019-00051

NSERC RGPIN-2017-06167

CFI IOF 32691

CFI JELF 36848

Ontario ER17-13-119

History

Email Address of Submitting Author

rylan.lundgren@ualberta.ca

Institution

University of Alberta

Country

Canada

ORCID For Submitting Author

0000-0002-7760-6946

Declaration of Conflict of Interest

The authors may hold provisional patents related to this work.

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