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Facile and Divergent Synthesis and Antifungal Evaluation of Drimane Meroterpenoids by Merging Decarboxylative Borylation and Suzuki Coupling

preprint
submitted on 25.08.2020, 00:33 and posted on 25.08.2020, 10:58 by Xia Wang, Shasha Zhang, Pengcheng Cui, Shengkun Li

Based on the easily accessible and inexpensive sclareol, the bench stable drimanyl BPin was achieved through oxidative degradation and decarboxylative borylation. The following Suzuki coupling of the borate intermediate was developed as a powerful platform for a large variety of drimane meroterpenoids, non-natural mimics and ring-distorted motifs. Key features include mild conditions, operational facility, broad substrate scope, scalability, and good chemofidelity and stereofidelity as well as the easy availability of the various coupling partners.

Expedient formal synthesis of a large number of complex natural products is feasible via the current methodology. The high degree of practicality of the current chemistry bodes well for the discovery sciences towards pharmaceutically important meroterpenoids or leads through detailed SAR study. The facile accessibility to drimane meroterpenoids and mimics allowed the unprecedented evaluation of these chemical entities as antifungal agents. The promising activity of the non-natural mimics may open a new window for structural optimization and the identification of new targets.

Funding

National Natural Science Foundation of China 21772094

National Natural Science Foundation of China 21977049

History

Email Address of Submitting Author

SKL505@outlook.com

Institution

Guizhou University

Country

People’s Republic of China

ORCID For Submitting Author

0000-0001-5458-0811

Declaration of Conflict of Interest

The authors declare no competing financial interest.

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