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Exploring Homogeneous Conditions for Mild Buchwald-Hartwig Amination in Batch and Flow

preprint
revised on 14.01.2020, 00:21 and posted on 14.01.2020, 13:18 by Saeed K. Kashani, Jacob E. Jessiman, Stephen Newman
We describe the use of high throughput experimentation to identify a number of conditions that enable Buchwald-Hartwig reactions to be carried out using readily available ligands (e.g. XantPhos) with DBU as a soluble, functional group tolerant, homogeneous base. Application of this system to diverse aminations in batch and flow are demonstrated, as is the translation of this technique to performing continuous Mizoroki-Heck and Sonogashira coupling reac-tions.

Funding

Natural Sciences and Engineering Research Council of Canada (NSERC)

Natural Sciences and Engineering Research Council

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History

Email Address of Submitting Author

stephen.newman@uottawa.ca

Institution

University of Ottawa

Country

Canada

ORCID For Submitting Author

0000-0003-1949-5069

Declaration of Conflict of Interest

The authors declare no conflict of interest

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in Organic Process Research & Development

ChemRxiv

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