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Exploring Homogeneous Conditions for Mild Buchwald-Hartwig Amination in Batch and Flow

preprint
revised on 14.01.2020 and posted on 14.01.2020 by Saeed K. Kashani, Jacob E. Jessiman, Stephen Newman
We describe the use of high throughput experimentation to identify a number of conditions that enable Buchwald-Hartwig reactions to be carried out using readily available ligands (e.g. XantPhos) with DBU as a soluble, functional group tolerant, homogeneous base. Application of this system to diverse aminations in batch and flow are demonstrated, as is the translation of this technique to performing continuous Mizoroki-Heck and Sonogashira coupling reac-tions.

Funding

Natural Sciences and Engineering Research Council of Canada (NSERC)

Natural Sciences and Engineering Research Council

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History

Email Address of Submitting Author

stephen.newman@uottawa.ca

Institution

University of Ottawa

Country

Canada

ORCID For Submitting Author

0000-0003-1949-5069

Declaration of Conflict of Interest

The authors declare no conflict of interest

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in Organic Process Research & Development

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