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Multimaterial Chemrxiv.pdf (1.99 MB)

Exploiting Generative Design for Multi-Material Inkjet 3D Printed Cell Instructive, Bacterial Biofilm Resistant Composites

preprint
submitted on 01.07.2020 and posted on 02.07.2020 by yinfeng he, Belen Begines, Gustavo Trindade, Meisam Abdi, Jean-Frédéric dubern, Elisabetta Prina, Andrew Hook, Gabriel Choong, Javier Ledesma, Christopher Tuck, Felicity R. A. J. Rose, Richard Hague, Clive Roberts, Davide De Focatiis, Ian Ashcroft, Paul Williams, Derek Irvine, Morgan alexander, Ricky Wildman

As our understanding of disease grows, it is becoming established that treatment needs to be personalized and targeted to the needs of the individual. In this paper we show that multi-material inkjet-based 3D printing, when backed with generative design algorithms, can bring a step change in the personalization of medical devices. We take cell-instructive materials known for their resistance to bacterial biofilm formation and reformulate for multi-material inkjet-based 3D printing. Specimens with customizable mechanical moduli are obtained without loss of their cell-instructive properties. The manufacturing is coupled to a design algorithm that takes a user-specified deformation and computes the distribution of the materials needed to meet the target under given load constraints. Optimisation led to a voxel map file defining where different materials should be placed. Manufactured products were assessed against the mechanical and cell-instructive specifications and ultimately showed how multifunctional personalization emerges from generative design driven 3D printing.

Funding

EPSRC Centre for Innovative Manufacturing in Additive Manufacturing

Engineering and Physical Sciences Research Council

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Formulation for 3D printing: Creating a plug and play platform for a disruptive UK industry

Engineering and Physical Sciences Research Council

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Enabling Next Generation Additive Manufacturing

Engineering and Physical Sciences Research Council

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EPSRC and MRC Centre for Doctoral Training in Regenerative Medicine

Engineering and Physical Sciences Research Council

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Bacterial Surface Sensing - to Stick or not to Stick?.

Wellcome Trust

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Bacterial Surface Sensing to Stick or not to Stick?.

Wellcome Trust

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History

Email Address of Submitting Author

ricky.wildman@nottingham.ac.uk

Institution

University of Nottingham

Country

United Kingdom

ORCID For Submitting Author

0000-0003-2329-8471

Declaration of Conflict of Interest

None

Version Notes

Version 1 Manuscript and Supplementary

Exports