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Exosome-Mimetic Supramolecular Vesicles with Reversible and Controllable Fusion and Fission

submitted on 02.06.2020, 03:14 and posted on 04.06.2020, 08:18 by Jie Li, KANG PENG, Youmei Li, Jianxing Wang, Jianbing Huang, Yun Yan, Dong Wang, Ben Zhong Tang

The fusion and fission behaviors of exosomes are essential for the cell-to-cell communication. Developing exosome-mimetic vesicles with such behaviors is of vital importance, but still remains a big challenge. Herein, we present an artificial supramolecular vesicle that exhibits redox-modulated reversible fusion-fission functions. These vesicles tend to fuse together and form large-sized vesicles upon oxidation, while undergo a fission process and return to smallsized vesicles through reduction. Noteworthy, the aggregationinduced emission (AIE) characteristics of the supramolecular building blocks enable the molecular configuration during vesicular transformation to be monitored by fluorescence technology. Moreover, the presented vesicles are excellent nanocarrier candidates to transfer siRNA into cancer cells.


Email Address of Submitting Author


Shenzhen University



ORCID For Submitting Author


Declaration of Conflict of Interest

The authors declare no conflict of interest.


Read the published paper

in Angewandte Chemie International Edition

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