ChemRxiv
These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
1/1
0/0

Exosome-Mimetic Supramolecular Vesicles with Reversible and Controllable Fusion and Fission

preprint
submitted on 02.06.2020 and posted on 04.06.2020 by Jie Li, KANG PENG, Youmei Li, Jianxing Wang, Jianbing Huang, Yun Yan, Dong Wang, Ben Zhong Tang

The fusion and fission behaviors of exosomes are essential for the cell-to-cell communication. Developing exosome-mimetic vesicles with such behaviors is of vital importance, but still remains a big challenge. Herein, we present an artificial supramolecular vesicle that exhibits redox-modulated reversible fusion-fission functions. These vesicles tend to fuse together and form large-sized vesicles upon oxidation, while undergo a fission process and return to smallsized vesicles through reduction. Noteworthy, the aggregationinduced emission (AIE) characteristics of the supramolecular building blocks enable the molecular configuration during vesicular transformation to be monitored by fluorescence technology. Moreover, the presented vesicles are excellent nanocarrier candidates to transfer siRNA into cancer cells.

History

Email Address of Submitting Author

leejie2012@163.com

Institution

Shenzhen University

Country

China

ORCID For Submitting Author

0000-0003-1193-5736

Declaration of Conflict of Interest

The authors declare no conflict of interest.

Exports

Read the published paper

in Angewandte Chemie International Edition

Logo branding

Categories

Exports