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Exogenous Directing Group Free, Ligand-Enabled gamma-C(sp3)–H Arylation of Free Primary Aliphatic Amines and α-Amino Esters

preprint
submitted on 01.12.2019 and posted on 10.12.2019 by Yongzheng Ding, Shuai Fan, Xiaoxi Chen, yuzhen gao, Gang Li
A Pdᴵᴵ-catalyzed, ligand-enabled gamma-C(sp3)–H arylation of free primary aliphatic amines and amino esters without using an exogenous directing group is reported. This reaction is compatible with unhindered free aliphatic amines, and it is also be applicable to the rapid synthesis of biologically and synthetically valuable unnatural α-amino acids. Large scale synthesis is also feasible using this method.

History

Email Address of Submitting Author

gangli@fjirsm.ac.cn

Institution

Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences

Country

China

ORCID For Submitting Author

0000-0001-5229-554X

Declaration of Conflict of Interest

no conflict of interest to declare

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