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Evaluation of Flavonoids as 2019-nCoV Cell Entry Inhibitor Through Molecular Docking and Pharmacological Analysis

preprint
submitted on 02.04.2020 and posted on 06.04.2020 by Deep Bhowmik, Rajat Nandi, Diwakar Kumar
In this study we aimed at the receipt binding domain of S protein and ACE-2 receptor as a promising drug targets against SARS-CoV-2. Flavonoids with anti-viral properties were taken as ligand for molecular docking. Selected flavonoids showed extremely good pharmacokinetics properties with good absorption, solubility, metabolism, excretion,distribution, bioavailability and minimal toxicity. These identified lead flavonoids may act as potential compound for the development of effective drugs and may help in controlling the rapid spread of SARS-CoV-2 by potentially inhibiting the virus entry into the host cell.

Funding

SERB-ECR, GOI grant (FILE NO. ECR/2015//000155)

DBT, GOI grant (order no: BT/PR16224/NER/95/176/2015)

DBT, GOI grant (order no: BT/PR24504/NER/95/746/2017)

History

Email Address of Submitting Author

diwakar11@gmail.com

Institution

Assam University

Country

India

ORCID For Submitting Author

0000-0002-3050-5179

Declaration of Conflict of Interest

no conflct of interest

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