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Energetic Control of Redox-Active Polymers Towards Safe Organic Bioelectronic Materials

submitted on 13.12.2019, 17:50 and posted on 20.12.2019, 06:00 by Alexander Giovannitti, Reem B. Rashid, Quentin Thiburce, Bryan D. Paulsen, Camila Cendra, Karl J. Thorley, Davide Moia, J. Tyler Mefford, David Hanifi, Weiyuan Du, Maximilian Moser, Alberto Salleo, Jenny Nelson, Iain McCulloch, Jonathan Rivnay

Avoiding faradaic side reactions during the operation of electrochemical devices is important to enhance the device stability, to achieve low power consumption, and to prevent the formation of reactive side‑products. This is particularly important for bioelectronic devices which are designed to operate in biological systems. While redox‑active materials based on conducting and semiconducting polymers represent an exciting class of materials for bioelectronic devices, they are susceptible to electrochemical side‑reactions with molecular oxygen during device operation. We show that this electrochemical side reaction yields hydrogen peroxide (H2O2), a reactive side‑product, which may be harmful to the local biological environment and may also accelerate device degradation. We report a design strategy for the development of redox-active organic semiconductors based on donor-acceptor copolymers that prevent the formation of H2O2 during device operation. This study elucidates the previously overlooked side-reactions between redox-active conjugated polymers and molecular oxygen in electrochemical devices for bioelectronics, which is critical for the operation of electrolyte‑gated devices in application-relevant environments.


EPSRC EP/G037515/1

EPSRC EP/N509486/1

TomKat Center for Sustainable Energy at Stanford University


Email Address of Submitting Author


Stanford University


United States

ORCID For Submitting Author


Declaration of Conflict of Interest

No conflict of interest

Version Notes

Manuscript version #1