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Enantioselective Addition of Pyrazoles to Dienes
preprintsubmitted on 26.04.2021, 23:16 and posted on 28.04.2021, 05:39 by Alexander Y. Jiu, Hannah Slocumb, Charles Yeung, Xiaohui Yang, Vy M. Dong
We report the first enantioselective addition of pyrazoles to 1,3-dienes. Secondary and tertiary allylic pyrazoles can be generated with excellent regioselectivity. Mechanistic studies support a pathway distinct from previous hydroaminations: a Pd(0)-catalyzed ligand-to?ligand hydrogen transfer (LLHT). This hydroamination tolerates a range of functional groups and provides a breakthrough in hydrofunctionalization of dienes.