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Enantioselective Access to Dialkyl Amines and Alcohols via Ni-Catalyzed Reductive Hydroalkylations

preprint
submitted on 25.11.2020, 02:54 and posted on 25.11.2020, 12:57 by Shan Wang, Tian-Yi Zhang, Jian-Xin Zhang, Huan Meng, Bi-Hong Chen
Chiral dialkyl amines and alcohols are ubiquitous in pharmaceuticals, pesticides, natural products and fine chemicals, yet difficult to access due to the challenge to differentiate between the spatially and electronically similar alkyl groups. Herein, we report a nickel-catalyzed enantioselective reductive hydroalkylation of enamides and enolates with alkyl halides to afford enantioenriched α-branched aliphatic amines and alcohols in good yields with excellent levels of enantioselectivity. The operationally simple protocol provides a straightforward access to chiral dialkyl amine and alcohol derivatives from simple starting materials with great functional group tolerance.

History

Email Address of Submitting Author

shuw@sustech.edu.cn

Institution

Southern University of Science and Technology

Country

China

ORCID For Submitting Author

0000-0003-0890-2634

Declaration of Conflict of Interest

none

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