Enantiomeric Excess Dependent Splitting of NMR Signal Through Co-Ligand Dynamic Exchange in a Coordination Complex

A coordination complex (L·2Zn·3C), where L is a prochiral ligand and C is an exchangeable acetate co-ligand, exhibits symmetrical splitting of 1H-NMR resonances due to L, which is proportional to the enantiomeric excess (ee) of a chiral guest co-ligand, 2-phenoxypropionic acid (PPA). The NMR resonances remain split even in dilute solution due to the high stability of complex with chiral guest.