ChemRxiv
These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
1/1
2 files
0/0

Emergency Antiviral Drug Discovery During a Pandemic - a Case Study on the Application of Natural Compounds to Treat COVID-19

preprint
submitted on 14.05.2020 and posted on 15.05.2020 by Jianfeng Yu, Shengxi Shao, Bin Liu, Zhihao Wang, Yi-Zhou Jiang, Yunqing Li, Feng Chen, Bing Liu

The spreading COVID-19 pandemic has brought the world to a halt in 2020. One of the major challenges is the lack of effective antiviral drugs. Drug and vaccine development typically takes years; a practical approach to formulate knowledge-based prescriptions is to conduct in silico screening for drugs and compounds that has the potential to disrupt viral protein functions. By evaluating the dataset from the “Shennong project”, an in silico screening of the DrugBank library against SARS-CoV-2 proteins, we identified chlorogenic acid and rutin displayed a strong affinity with diverse viral proteins. Chlorogenic acid is naturally present in coffee in large quantity, and rutin is available as nutraceutical products, both compounds are considered safe to consume, hence could potentially aid the recovery or treatment for COVID-19 patients at low health risk. We emphasise that the results require further clinical clarification, the impact of this work shall be examined by professionals carefully.

History

Email Address of Submitting Author

j.yu@imperial.ac.uk

Institution

Shenzhen University

Country

China

ORCID For Submitting Author

0000-0001-7174-3803

Declaration of Conflict of Interest

No conflict of interest

Exports

Logo branding

Exports