Electrochemical TEMPO-Catalyzed Multicomponent C(sp3)-H α-Carbamoylation of Free Cyclic Secondary Amines

We report here an original electrosynthetic method allowing the straightforward C(sp3)-H a-carbamoylation of free cyclic secondary amines. Based on a TEMPO-catalyzed indirect anodic oxidation and a multicomponent coupling, a wide variety of N-acyl alpha-carboxamides have been obtained in remarkably mild and sustainable reaction conditions.