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Electrochemical Borylation of Carboxylic Acids

preprint
submitted on 12.03.2021, 22:13 and posted on 16.03.2021, 05:44 by Lisa M. Barton, Longrui Chen, Donna Blackmond, Phil Baran
A simple electrochemically mediated method for the conversion of alkyl carboxylic acids to their borylated congeners is presented. This protocol features an undivided cell setup with inexpensive carbon-based electrodes and exhibits a broad substrate scope and scalability in both flow and batch reactors. The use of this method in challenging contexts is exemplified with a modular formal synthesis of jawsamycin, a natural product harboring five cyclopropane rings.

Funding

NIGMS CCMF

National Institute of General Medical Sciences

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History

Email Address of Submitting Author

pbaran@scripps.edu

Institution

Scripps Research

Country

USA

ORCID For Submitting Author

0000-0001-9193-9053

Declaration of Conflict of Interest

none

Version Notes

version 1.0

Exports