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IgG for ChemRXIV_Paper Final.pdf (744.45 kB)
Electrochemical-Based Serological Detection of Bovine Immunoglobulin G in Calves
Preprints are manuscripts made publicly available before they have been submitted for formal peer review and publication. They might contain new research findings or data. Preprints can be a draft or final version of an author's research but must not have been accepted for publication at the time of submission.
submitted on 03.02.2020 and posted on 04.02.2020by Caoimhe Robinson, Niamh Creedon, Riona sayers, emer kennedy, Alan O'Riordan
antibodies, such as immunoglobulin G (IgG), cannot pass the placental barrier
and as such are not transferred from the mother to the foetus, in utero. Instead a calf must absorb antibodies following
ingestion of colostrum postpartum. Failure
of Passive Transfer (FPT) is a condition that predisposes calves to development
of disease and increases the risk of mortality.
Thus, continuous early monitoring of IgG absorption in a calf, within
the first 24 hours of life, is imperative to allow faster treatment and prevent
FPT. In this paper, we present the
development of a label-free impedimetric immunosensor device for bovine IgG in
serum and demonstrate its suitability to determine early FPT in new-born calves.
The developed sensors were challenged to discriminate between new born calf sera,
both pre- and post-colostrum feeding, and demonstrated efficent detection of IgG
in under 15 minutes. Such a device could enable rapid determination of FPT,
thereby improving calves’ vitality and survival rate