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IgG for ChemRXIV_Paper Final.pdf (744.45 kB)
Electrochemical-Based Serological Detection of Bovine Immunoglobulin G in Calves
Preprints are manuscripts made publicly available before they have been submitted for formal peer review and publication. They might contain new research findings or data. Preprints can be a draft or final version of an author's research but must not have been accepted for publication at the time of submission.
submitted on 03.02.2020, 15:05 and posted on 04.02.2020, 10:34by Caoimhe Robinson, Niamh Creedon, Riona sayers, emer kennedy, Alan O'Riordan
antibodies, such as immunoglobulin G (IgG), cannot pass the placental barrier
and as such are not transferred from the mother to the foetus, in utero. Instead a calf must absorb antibodies following
ingestion of colostrum postpartum. Failure
of Passive Transfer (FPT) is a condition that predisposes calves to development
of disease and increases the risk of mortality.
Thus, continuous early monitoring of IgG absorption in a calf, within
the first 24 hours of life, is imperative to allow faster treatment and prevent
FPT. In this paper, we present the
development of a label-free impedimetric immunosensor device for bovine IgG in
serum and demonstrate its suitability to determine early FPT in new-born calves.
The developed sensors were challenged to discriminate between new born calf sera,
both pre- and post-colostrum feeding, and demonstrated efficent detection of IgG
in under 15 minutes. Such a device could enable rapid determination of FPT,
thereby improving calves’ vitality and survival rate