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Effect of the Air-Water Interface on the Conformation of Amyloid Beta

preprint
submitted on 14.09.2020 and posted on 16.09.2020 by Suman Samantray, David Cheung
Using MD simulation the conformation of the fibril forming protein amyloid beta at the air-water interface. It is found that adsorption at the air-water interface induces the formation of aggregation prone alpha-helical conformations, consistent with experimental studies of amyloid beta. Adsorption on the air-water interface also reduces the number of distinct conformations that the protein exhibits. This provides insight into the role of protein conformational change into the enhancement of protein fibrillation at interfaces.

History

Email Address of Submitting Author

david.cheung@nuigalway.ie

Institution

NUI Galway

Country

Ireland

ORCID For Submitting Author

0000-0002-3994-2295

Declaration of Conflict of Interest

no conflict of interest

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